Webinar recording now available: Identifying and targeting unconventional druggable sites on pathological amyloid fibrils

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Join us for an exciting presentation by Dr. Sylvie Hermouet on the cutting-edge multiplexed infectious antigen micro-array (MIAA) assay and its potential to revolutionize the diagnosis and treatment of multiple myeloma, smoldering myeloma, and monoclonal gammopathy of undetermined significance.

Discover Dr. Hermouet's work. She has identified monoclonal Igs that recognize pathogens causing chronic infections and the promising results of anti-viral therapy in controlling the plasmacytic clone and reducing monoclonal Ig production in MM patients.

Additionally, learn how the PEPperCHIP^® Infectious Disease Epitope Microarray was used to identify sequences of Enterovirus VP1 proteins recognized by a small percentage of purified monoclonal Igs. Don't miss out! Register now to receive the recording if you can't attend live.

Abstract
Multiple myeloma (MM), its preceding stages, smoldering myeloma (SMM), and monoclonal gammopathy of undetermined significance (MGUS) are characterized by the presence of a mutated plasmacytic clone that produces large amounts of a single immunoglobulin (Ig), called monoclonal Ig. Over the years, the size of the plasmacytic clone and the quantity of monoclonal Ig increase when MGUS progresses toward SMM, then to overt MM. Thus, monoclonal Ig is a major marker of disease evolution. Yet its role in MGUS, SMM, and MM remains poorly understood, and the monoclonal Ig is not a target in the treatment of MM.

Reasoning that most Ig's are produced to fight infections, we designed a new assay, called the multiplexed infectious antigen micro-array (MIAA) assay, which allows determining whether purified monoclonal Igs from MGUS, SMM, or MM patients target infectious pathogens. Using the MIAA assay, we were able to show that >50% of MGUS patients, >40% of SMM patients, and 30% of MM patients present with a monoclonal Ig that specifically recognizes a pathogen that causes chronic infection, notably Hepatitis C and B viruses (HCV, HBV), Helicobacter pylori and Herpesviruses. MGUS and MM disease in these patients is likely initiated by infection since anti-viral therapy can lead to the disappearance of antigenic stimulation, control of the plasmacytic clone, and reduced or suppressed production of the monoclonal Ig, as demonstrated recently for MM patients presenting with a monoclonal Ig specific for HCV or HBV (Front Immunol 2022, Haematologica 2023).

In addition, the PEPperCHIP^® Infectious Disease Epitope Microarray was used to identify sequences of Enterovirus VP1 proteins recognized by ~7% purified monoclonal Igs. In summary, this presentation describes results obtained using the MIAA assay or PEPperCHIP^® Microarrays, to identify targets of monoclonal Ig's, and the importance and interest for patients of treatments that reduce or suppress the target of their monoclonal Ig, when the monoclonal Ig reacts against a treatable infectious pathogen.

About the presenter:

Dr. Sylvie Hermouetis an MD Ph.D., Associate Professor in Hematology at the Medical School of Nantes, in France, a Hemato-Biologist at the University Hospital of Nantes, and a Researcher at Inserm UMR1302 (INCIT), also in Nantes, specialized in the biology and diagnosis of myeloproliferative neoplasms (MPN), multiple myeloma and monoclonal gammopathies of undetermined significance (MGUS).

Member of European LeukemiaNet (MPN working group, since 2008)
Chair of MPN&MPNr-EuroNet (2009-2021) (COST Action BM0902, 2009-2013)
International Myeloma Foundation (IMF) 2020 Brian D. Novis Research Award
International Myeloma Foundation (IMF) 2021 Black Swan Research Initiative Award

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